Clinical Trial Information Mediator

Integrating Clinical and Genomic Information Through the PrognoChip Mediator

The ultimate goal of the biomedical informatics project PrognoChip is the identification of classification and prognosis molecular markers for breast cancer. This requires not only an understanding of the genetic basis of the disease, based on the patient’s tumor gene expression profiles but also the correlation of this data with knowledge normally processed in the clinical setting. In this pap...

A new register for clinical trial information.

K-Mediator: Towards Evolving Information Systems

Business processes and goals change rapidly due to the turbulent environment in which they operate. Their supporting and underpinning technologies may, as a result, require to change. Meanwhile, technological advances are being made at an increasing rate. This may trigger changes in business goals and processes to exploit these new advances; a notable example is e-commerce and e-learning. Under...

A security mediator for health care information.

The TIHI (Trusted Interoperation of Healthcare Information) project addresses a security issue that arises when some information is being shared among collaborating enterprises, although not all enterprise information is sharable. It assumes that protection exists to prevent intrusion by adversaries through secure transmission and firewalls. The TIHI system design provides a gateway, owned by t...

Query Processing in an Information Mediator

A critical problem in building an information mediator is how to translate a domain-level queries into an e cient query plan for accessing the required data. We have built a exible and e cient information mediator, called SIMS. SIMS takes a domain-level query and dynamically selects the appropriate information sources based on their content and availability, generates a query access plan that s...